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Completed stroke was present in eight patients,and 15 reported transient neurological deficits.Magnetic resonance imaging yielded cerebral abnormalities in 16 or 17,whereas computed tomographic scans were abnormal in only 12 of 16 patients.Magnetic resonance imaging revealed more lesions in individual patients than did computed tomography.Magnetic resonance angiography demonstrated patent intracranial vessels in 16 of 17 patients. Skin biopsy showed distinct histopathological findings in all patients.The involved vessels were small to medium-sized arteries at the border between dermis and subcutis.Early inflammatory reactions were followed by subendothelial proliferation and a late fibrotic stage.Laboratory examinations showed impaired creatinine clearance in eight patients, whereas all other laboratory tests,including antiphospholipid antibodies, were normal.In this series,magnetic resonance imaging and skin biopsy were useful for confirmation of the diagnosis of Sneddon's syndrome.Magnetic resonance findings were not specific,but the high sensitivity for detection of asymptomatic brain lesions helped to confirm the diagnosis in patients with transient symptoms.Histological features of skin biopsies were characteristic if appropriate techniques were employed. |
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CAT scan
CAT scan,abnormal
cerebrovascular accident
headache
livedo reticularis
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MRI,abnormal
MRI,high signal foci on
neurologic disease,diagnoses of
skin,biopsy
skin,lesions in neurologic disorders
Sneddon's syndrome
transient ischemic attack
transient neurologic deficit
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